Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer

Sansom, Owen J., Maddison, Kathryn and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2007. Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nature Clinical Practice Oncology 4 (5) , pp. 305-315. 10.1038/ncponc0812

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Abstract

The methyl-CpG-binding domain (MBD) proteins 'read' and interpret the methylation moieties on DNA, and thus are critical mediators of many epigenetic processes. Currently, the MBD family comprises five members; MBD1, MBD2, MBD3, MBD4 and MeCP2. Although not a 'classical' MBD protein, Kaiso also mediates transcriptional repression by using zinc finger domains to bind its targets. Since DNA hypermethylation is a well-recognized mechanism underlying gene silencing events in both tumorigenesis and drug resistance, it is likely that the MBD proteins may be important modulators of tumorigenesis. We review the recent work addressing this possibility, and discuss several of the MBD proteins as potentially excellent novel therapeutic targets.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
ISSN:	1743-4254
Last Modified:	25 Oct 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/61342

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