DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data

Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Hay, Trevor 2005. DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data. Biochemical Society Transactions 33 (4) , pp. 715-717. 10.1042/BST0330715

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Abstract

Since the discovery of the tumour suppressor BRCA2 (encoded by breast-cancer susceptibility gene 2), cells lacking the fully functional protein have consistently been found to show increased sensitivity to a variety of DNA-damaging agents, particularly those that cross-link DNA. In this short review, we will bring together these findings and discuss them in the light of our recent in vivo data in the mouse small intestine, which suggests that deletion of cells lacking Brca2 is necessary to avoid the development of potentially tumorigenic clones in this tissue, a system that may be less effective in the mammary glands of humans with germline mutations in BRCA2.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Apoptosis; Brca2; cross-linking agents; DNA damage; hypersensitivity; small intestine.
Publisher:	Portland Press
ISSN:	0300-5127
Last Modified:	25 Oct 2022 10:11
URI:	https://orca.cardiff.ac.uk/id/eprint/61352

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