MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2005. MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene 24 (14) , pp. 2430-2432. 10.1038/sj.onc.1208166

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Abstract

Recent studies using hypomorphic DNA methyltransferase 1 (DNMT1) alleles have suggested that strategies aiming to reduce DNA methylation may increase genomic instability and lymphomagenesis. Given our recent finding that loss of methyl-binding domain protein 2 (Mbd2) suppresses intestinal tumorigenesis, we have tested whether loss of Mbd2 increases lymphomagenesis by intercrossing Mbd2 deficient mice with p53 deficient and p53 heterozygous mice. Unlike DNMT1, loss of Mbd2 does not accelerate lymphomagenesis, arguing that MBD2 may represent a better potential therapeutic target than DNMT1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	MBD2; p53; DNA methylation; tumorigenesis; chemoprevention; genomic instability.
Publisher:	Nature Publishing
ISSN:	0950-9232
Last Modified:	25 Oct 2022 10:11
URI:	https://orca.cardiff.ac.uk/id/eprint/61356

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