Thewt1-heterozygous mouse; a model to study the development of glomerular sclerosis

Menke, Aswin L., IJpenberg, Annemieke, Fleming, Stewart, Ross, Allyson, Medine, Claire N., Patek, Charles E., Spraggon, Lee, Hughes, Jeremy, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Hastie, Nicholas D. 2003. Thewt1-heterozygous mouse; a model to study the development of glomerular sclerosis. The Journal of Pathology 200 (5) , pp. 667-674. 10.1002/path.1390

Full text not available from this repository.

Abstract

In the present study, it is shown that mice heterozygous for wt1 develop glomerular sclerosis and the nature and time course of events leading to the glomerular scarring are determined. Wt1-heterozygous (wt1het) mice and their wild-type littermates were closely monitored from birth and plasma levels of urea, creatinine, and albumin were compared with histological data and clinical features. One of the first indications of nephropathy in the wt1het mouse was the development of proteinuria, accompanied by progressive elevation of the plasma levels of urea and creatinine. Subsequently, the mice developed albuminuria, which correlated with thickening of the glomerular basement membrane and fusion of the podocyte foot processes. Glomerulosclerosis was a relatively late event, accompanied by severe albuminuria and loss of WT1, nephrin, CD2AP, and α-actinin-4.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	WT1; nephrin; CD2AP; α-actinin-4; sclerosis; albuminuria; kidney; podocytes; proteinuria.
Publisher:	Wiley
ISSN:	0022-3417
Last Modified:	25 Oct 2022 10:11
URI:	https://orca.cardiff.ac.uk/id/eprint/61366

Citation Data

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item