PPARδ status and mismatch repair mediated neoplasia in the mouse intestine

Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113

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Abstract

Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARδ) activity in the context of intestinal tumourigenesis remain somewhat unclear. Contradictory evidence suggesting PPARδ either attenuates or potentiates intestinal neoplasia. To further investigate the PPARδ dependency of intestinal tumourigenesis, we have analysed the consequences of PPARδ deficiency upon intestinal neoplasia occurring in mice with impaired mismatch DNA repair.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > Q Science (General) Q Science > QL Zoology
Additional Information:	PDF uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1471-2407/ [accessed 16/10/14]
Publisher:	BioMed Central
ISSN:	1471-2407
Date of First Compliant Deposit:	30 March 2016
Last Modified:	06 May 2023 19:19
URI:	https://orca.cardiff.ac.uk/id/eprint/61419

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