Brunello, Eleonora, Bogina, Giuseppe, Bria, Emilio, Vergine, Marco, Zamboni, Giuseppe, Pedron, Serena, Daniele, Isabella, Furlanetto, Jenny, Carbognin, Luisa, Marconi, Marcella, Manfrin, Erminia, Ibrahim, Merdol, Miller, Keith, Tortora, Giampaolo, Molino, Annamaria, Jasani, Bharat, Beccari, Serena, Bonetti, Franco, Chilosi, Marco, Martignoni, Guido and Brunelli, Matteo 2013. The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma. Journal of Cancer Research and Clinical Oncology 139 (9) , pp. 1563-1568. 10.1007/s00432-013-1479-0 |
Abstract
Purpose: Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. We sought to recruit from a group of triple negative breast carcinoma, patients eligible for effective personalized targeted therapy with anti-HER therapies on the basis of their HER2 gene status. Methods: 135 patients diagnosed with IHC triple negative breast carcinoma were studied. Whole tissue sections were used for in situ hybridization analysis. Results: 8/100 (8 %) of ductal-type triple negative breast carcinoma presented Her-2/neu gene amplification versus 2/35 (5.7 %) non-ductal triple negative breast carcinoma. Three cases showed a ratio 2.5. One case showed Her-2/neu heterogeneous gene amplification, ratio 2.3. The other six showed from 7 to 8 absolute Her-2/neu gene copy number. Two cases staged pT1c, and eight cases staged pT2. Eight cases graded G3 and two cases G2. Conclusion: (1) Eight percentage of ductal and 5.7 % non-ductal-type triple negative breast carcinoma present Her-2/neu gene amplification, (2) the standard diagnostic flowchart “do not FISH in 0–1+ (HER2-) breast carcinoma” should be replaced by “do FISH in triple (ER-, PR-, HER2-) negative breast carcinoma,” to avoid loss of therapeutical chances in a cohort of such a patients, (3) we demonstrated the identification of a small but significant subset of patients targetable with anti-HER2 inhibitors, giving patients affected by (ex)triple negative breast carcinoma new personalized therapeutical chances.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RG Gynecology and obstetrics |
Uncontrolled Keywords: | Triple negative breast carcinoma; Her-2/neu gene amplification; In situ hybridization; Trastuzumab |
Publisher: | Springer |
ISSN: | 0171-5216 |
Last Modified: | 18 Mar 2023 02:08 |
URI: | https://orca.cardiff.ac.uk/id/eprint/61465 |
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