IRES elements: features of the RNA structure contributing to their activity

Martinez-Salas, Encarnacion, Lopez De Quinto, Sonia ORCID: https://orcid.org/0000-0003-2990-281X, Ramos, Ricardo and Fernandez-Miragall, Olga 2002. IRES elements: features of the RNA structure contributing to their activity. Biochimie 84 (8) , pp. 755-763. 10.1016/S0300-9084(02)01408-6

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Abstract

The activity of internal ribosome entry site (IRES) elements depends on their structural organization. We have addressed here the study of conserved structural motifs in the foot-and-mouth disease virus (FMDV) IRES as an example to understand the relationship between RNA structure and function. The features of the RNA structure known to be functionally relevant are discussed in regards to the capacity to modulate interaction of translation initiation factors with the FMDV IRES element. Additionally, the contribution of non-canonical RNA-binding proteins to FMDV IRES organization as well as stimulation of its activity by other mRNA regions is discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Translation initiation; IRES; RNA structure; RNA-protein interaction.
Publisher:	Elsevier
ISSN:	0300-9084
Last Modified:	25 Oct 2022 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/61567

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