Homology modelling of the catalytic domain of early mammalian protein C: evolution of structural features

Wacey, A. I., Krawczak, M., Kemball-Cook, G. and Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484 1997. Homology modelling of the catalytic domain of early mammalian protein C: evolution of structural features. Human Genetics 101 (1) , pp. 37-42. 10.1007/s004390050582

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Abstract

By means of a novel cDNA-based strategy employing the maximum parsimony principle, we have previously deduced probable amino acid sequences for the catalytic domains of the early mammalian ancestors of each of the five extant vitamin K-dependent serine proteases of coagulation, and for their common ancestor from a still earlier stage of vertebrate evolution. In the present study, we employed one of these sequences to construct a molecular model of the catalytic domain of early mammalian protein C and to explore its functional architecture. Following the domain's progression from the common ancestor of the vitamin K-dependent serine proteases toward extant human protein C, this novel application of homology modelling to a reconstructed amino acid sequence has allowed us to trace the evolution of structural features in a vital coagulation protein.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Springer Verlag
ISSN:	0340-6717
Last Modified:	25 Oct 2022 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/61575

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