Glycogen synthase kinase 3: A key regulator of cellular fate

Forde, Josephine and Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2007. Glycogen synthase kinase 3: A key regulator of cellular fate. Cellular and Molecular Life Sciences 64 (15) , pp. 1930-1944. 10.1007/s00018-007-7045-7

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Abstract

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to function in a wide range of cellular processes including differentiation, growth, motility and apoptosis. Aberrant regulation of GSK-3 has been implicated in a range of human pathologies including Alzheimer’s disease, non-insulin-dependent diabetes mellitus (NIDDM) and cancer. As a consequence, the regulation of GSK-3 and the therapeutic potential of GSK-3 inhibitors have become key areas of investigation. This review will focus on the mechanisms of GSK-3 regulation, with emphasis on modulation by upstream signals, control of substrate specificity and GSK-3 localisation. The details of these mechanisms will be discussed in the context of specific signalling pathways.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Glycogen synthase kinase-3 (GSK-3); mechanism of action; inhibitors; signalling; disease; kinase; regulation.
Publisher:	Springer Verlag
ISSN:	1420-682X
Funders:	BBSRC
Last Modified:	22 Jun 2023 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/61752

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