Regional localization and characterization of a DNA segment on the long arm of chromosome 21

Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484, Niemann, S. C., Gosden, J. R., Mitchell, A. R., Goate, A. M., Rajendran, G. S., Miller, D. A., Lim, L. and Schmidtke, J. 1987. Regional localization and characterization of a DNA segment on the long arm of chromosome 21. Human Genetics 75 (2) , pp. 129-135. 10.1007/BF00591073

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Abstract

A human genomic DNA fragment, pAM37 (HGM8; D21S22), was mapped to chromosome 21q2.1-q2.21 by in situ hybridization. This segment is therefore situated on the boundary of the “pathological region” of Down syndrome. A genomic restriction map encompassing 35 kb of chromosome 21 was derived and two restriction fragment length polymorphisms (RFLPs) were mapped and characterized. A homologous sequence was detected in the mouse genome but no homologous RNA was detected in a range of human tissues. This DNA segment will contribute to the linkage mapping of chromosome 21 and will facilitate delineation of the pathological region of Down syndrome.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Springer
ISSN:	0340-6717
Last Modified:	27 Oct 2022 08:21
URI:	https://orca.cardiff.ac.uk/id/eprint/62068

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