Is LBP-1c/CP2/LSF a disease-modifying gene for Alzheimer's disease?

Lendon, Corinne and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2001. Is LBP-1c/CP2/LSF a disease-modifying gene for Alzheimer's disease? The Lancet 358 (9287) , pp. 1029-1030. 10.1016/S0140-6736(01)06228-6

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Abstract

Several years ago reports linked an area on chromosome 12 with Alzheimer's disease.1 More recently, two groups have reported a relation between a candidate gene (LBP-1c/CP2/LSF) on chromosome 12 and modified risk of Alzheimer's disease. 2 and 3 The region of chromosome 12 where several genetic linkage studies have found high lod scores4, 5, 6, 7, 8 and 9 is shown in the figure. The pattern of findings, modest evidence of linkage across a broad region of interest, can occur in complex genetic disorders such as Alzheimer's disease but this pattern could also be a false positive. Two potential candidate genes that lie within this region are genes for α−2 macroglobulin and LDL-receptor-related protein (LRP). α−2 macroglobulin is thought to be involved in the clearance and degradation of β-amyloid, a fragment of the amyloid precursor protein (APP) that is deposited in the brains of patients with Alzheimer's disease. LRP is a receptor for apolipoprotein E and α−2 macroglobulin. Casecontrol studies suggested that variants in α−2 macroglobulin10 and LRP11 were associated with a high risk of Alzheimer's disease. However, several subsequent studies have not corroborated these findings.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0140-6736
Last Modified:	27 Oct 2022 08:24
URI:	https://orca.cardiff.ac.uk/id/eprint/62175

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