No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis

Robertson, E., Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Middle, F., Moray, J. and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2003. No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis. Acta Psychiatrica Scandinavica 108 (5) , pp. 387-391. 10.1034/j.1600-0447.2003.00167.x

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Abstract

Objective: To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0001-690X
Last Modified:	27 Oct 2022 08:24
URI:	https://orca.cardiff.ac.uk/id/eprint/62186

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