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No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis

Robertson, E., Jones, Ian Richard ORCID:, Middle, F., Moray, J. and Craddock, Nicholas John ORCID: 2003. No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis. Acta Psychiatrica Scandinavica 108 (5) , pp. 387-391. 10.1034/j.1600-0447.2003.00167.x

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Objective: To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0001-690X
Last Modified: 27 Oct 2022 08:24

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