Death of injured neurons caused by the precursor of nerve growth factor

Barde, Yves-Alain ORCID: https://orcid.org/0000-0002-7627-461X 2004. Death of injured neurons caused by the precursor of nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America 101 (16) , pp. 5703-5704. 10.1073/pnas.0401374101

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Abstract

Because the adult mammalian brain has a very limited capacity to replace neurons lost after lesion (1), understanding the mechanisms regulating their survival or elimination is of special significance. A study in this issue of PNAS (2) reveals that cutting the axons of a neuronal population involved in movement control leads to a progressive and dramatic increase of pro-nerve growth factor (NGF) in brain fluids. Pro-NGF kills injured neurons by virtue of its high affinity binding to a receptor that is induced after axotomy, the neurotrophin receptor p75. Another recent study also indicates that neurons may not be the only targets of pro-NGF-mediated killing: after partial transaction of the spinal cord, oligodendrocytes may also be eliminated by the mechanism described by Harrington and colleagues (3).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	National Academy of Sciences
ISSN:	0027-8424
Last Modified:	27 Oct 2022 08:26
URI:	https://orca.cardiff.ac.uk/id/eprint/62298

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