Circadian dependency of nocturnal immediate-early protein induction in rat retina

Humphries, Ann and Carter, David Allan 2004. Circadian dependency of nocturnal immediate-early protein induction in rat retina. Biochemical and Biophysical Research Communications 320 (2) , pp. 551-556. 10.1016/j.bbrc.2004.06.006

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Abstract

Daily rhythms in the mammalian retina are regulated by an endogenous circadian clock. Previously it was found that neuronal elements of the rat retina respond to light:dark (L:D) transitions with cell-specific changes in expression of the c-fos gene. Using a pan-Fos antibody to probe Western blots of rat retina, we have now shown that darkness is associated with a 60-fold increase in c-Fos protein, whereas levels of FosB and Fos-related antigens are invariant. The induction of c-Fos exhibits circadian dependency; accumulation of c-Fos protein was significantly enhanced, by a factor of 2.5-fold, when darkness onset was coincident with the established L:D transition. c-Fos exhibited only a low amplitude circadian rhythm in the absence of L:D cycles. Similar results were obtained for another immediate early gene (IEG) protein, Egr-1. These findings show that IEG induction in the rodent retina exhibits circadian clock dependency.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0006-291X
Last Modified:	04 Jun 2017 06:34
URI:	https://orca.cardiff.ac.uk/id/eprint/62327

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