The corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease

Döbrössy, Máté D. and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2007. The corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease. Behavioural Brain Research 179 (2) , pp. 326-330. 10.1016/j.bbr.2007.02.030

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Abstract

Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	27 Oct 2022 08:27
URI:	https://orca.cardiff.ac.uk/id/eprint/62347

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