Dopamine neuron systems in the brain: an update

Björklund, Anders and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2007. Dopamine neuron systems in the brain: an update. Trends in Neurosciences 30 (5) , pp. 194-202. 10.1016/j.tins.2007.03.006

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Abstract

The basic organization of the catecholamine-containing neuronal systems and their axonal projections in the brain was initially worked out using classical histofluorescence techniques during the 1960s and 1970s. The introduction of more versatile immunohistochemical methods, along with a range of highly sensitive tract-tracing techniques, has provided a progressively more detailed picture, making the dopamine system one of the best known, and most completely mapped, neurotransmitter systems in the brain. The purpose of the present review is to summarize our current knowledge of the diversity and neurochemical features of the nine dopamine-containing neuronal cell groups in the mammalian brain, their distinctive cellular properties, and their ability to regulate their dopaminergic transmitter machinery in response to altered functional demands and aging.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Cell Press
ISSN:	0166-2236
Last Modified:	27 Oct 2022 08:27
URI:	https://orca.cardiff.ac.uk/id/eprint/62348

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