Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease

Torres, Eduardo Miguel and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2007. Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease. European Neuropsychopharmacology 17 (3) , pp. 206-214. 10.1016/j.euroneuro.2006.04.009

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Abstract

In the unilateral rat model of Parkinson's disease (PD), amphetamine induced rotation is widely used as an index of both lesion deficits and of graft-derived recovery. We have analysed the time course of the rotational response in lesioned rats, and in rats with lesions and dopamine grafts. In lesioned rats, the rotation exhibited a typical dose-dependent response, with low rates of rotation in the first 10 min after injection, rising gradually to a maximum after 20–30 min. Grafted rats exhibited a peak of rotation in the first 10 min after injection, which then fell to a minimum after 30 min. We demonstrate that the response seen in grafted rats is both drug and dose-dependent and show that the rotational profile results from interaction of the grafted and intact striata which exhibit differential temporal responses to the amphetamine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0924-977X
Last Modified:	27 Oct 2022 08:27
URI:	https://orca.cardiff.ac.uk/id/eprint/62353

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