A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder

Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Norton, N., Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, McCandless, F., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1999. A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. International Journal of Neuropsychopharmacology 2 (4) , pp. 293-298. 10.1017/s1461145799001601

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Abstract

The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to their children affected with bipolar disorder (chi(2) = 2.75, 4 d.f., p = 0.6). Following on our previous finding of an excess of low-activity genotypes of catechol-O-methyltransferase in patients with a rapid cycling form of illness, we examined for a similar trend with MAOA alleles. In an extended sample we found a non-significant trend for patients with an ultra-rapid cycling form of illness (n = 29) to have a higher frequency of low-activity alleles compared with 92 bipolar patients with a non-rapid cycling course of illness (chi(2) = 2.37, 1 d.f., p = 0.13).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Additional Information:	Grant Support G9810900/Medical Research Council/United Kingdom
Publisher:	Cambridge University Press
ISSN:	1461-1457
Last Modified:	27 Oct 2022 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/63048

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