Knot, Harm J., Laher, Ismail, Sobie, Eric A., Guatimosim, Silvia, Gomez-Viquez, Leticia, Hartmann, Hali, Song, Long-Sheng, Lederer, W. J., Graier, Wolfgang F., Malli, Roland, Frieden, Maud and Petersen, Ole Holger  ORCID: https://orcid.org/0000-0002-6998-0380
2005.
Twenty years of calcium imaging: cell physiology to dye for.
Molecular Interventions
5
(2)
, pp. 112-127.
10.1124/mi.5.2.8
|
Abstract
The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Publisher: | American Society for Pharmacology and Experimental Therapeutics |
| ISSN: | 1534-0384 |
| Related URLs: | |
| Last Modified: | 27 Oct 2022 08:41 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/63131 |
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