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Twenty years of calcium imaging: cell physiology to dye for

Knot, Harm J., Laher, Ismail, Sobie, Eric A., Guatimosim, Silvia, Gomez-Viquez, Leticia, Hartmann, Hali, Song, Long-Sheng, Lederer, W. J., Graier, Wolfgang F., Malli, Roland, Frieden, Maud and Petersen, Ole Holger 2005. Twenty years of calcium imaging: cell physiology to dye for. Molecular Interventions 5 (2) , pp. 112-127. 10.1124/mi.5.2.8

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The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Publisher: American Society for Pharmacology and Experimental Therapeutics
ISSN: 1534-0384
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Last Modified: 04 Jun 2017 06:38

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