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Cerd4, third member of the d4 gene family: expression and organization of genomic locus

Ninkina, Natalia ORCID:, Mertsalov, Ilja B., Kulikova, Dina A., Alimova-Kost, Maria V., Simonova, Olga B., Korochkin, Leonid I., Kiselev, Sergey L. and Buchman, Vladimir L. ORCID: 2001. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. Mammalian Genome 12 (11) , pp. 862-866. 10.1007/s00335-001-3039-1

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Two members of the d4 family of presumptive transcription modulators, neuro-d4 (Neud4) and ubi-d4/Requiem (Req), have been characterized previously. We cloned and characterized the third member of this gene family, cer-d4 (Cerd4), from chicken and mouse cDNA libraries. The expression patterns of Cerd4 gene in both species are similar and more restricted than expression patterns of other two d4 genes. The main sites of Cerd4 expression are retina and cerebellum, where multiple transcripts could be detected. Two major types of Cerd4 proteins are a full-length isoform possessing all domains characteristic to the d4 family and truncated XZ isoform without C-terminal tandem of PHD fingers. The developmental kinetics of expression of these isoforms is different. The intron/exon structure of human Cerd4 gene is similar to that of neuro-d4 and ubi-d4/Requiem genes, but most introns of Cerd4 gene are much larger than the corresponding introns of the other two genes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer Verlag
ISSN: 0938-8990
Last Modified: 27 Oct 2022 08:45

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