Hogan, Catherine  ORCID: https://orcid.org/0000-0002-1012-0896, Serpente, N., Cogram, P., Hosking, C. R., Bialucha, C. U., Feller, S. M., Braga, V. M. M., Birchmeier, W. and Fujita, Y.
2004.
Rap1 regulates the formation of E-Cadherin-based cell-cell contacts.
Molecular and Cellular Biology
24
(15)
, pp. 6690-6700.
10.1128/MCB.24.15.6690-6700.2004
|
Abstract
In epithelial tissues, cells are linked to their neighbors through specialized cell-cell adhesion proteins. E-cadherin is one of the most important membrane proteins for the establishment of intimate cell-cell contacts, but the molecular mechanism by which it is recruited to contact sites is largely unknown. We report here that the cytoplasmic domain of E-cadherin interacts with C3G, a guanine nucleotide exchange factor for Rap1. In epithelial cell cultures, ligation of the extracellular domain of E-cadherin enhances Rap1 activity, which in turn is necessary for the proper targeting of E-cadherin molecules to maturing cell-cell contacts. Furthermore, our data suggest that Cdc42 functions downstream of Rap1 in this process. We conclude that Rap1 plays a vital role in the establishment of E-cadherin-based cell-cell adhesion.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Research Institutes & Centres > European Cancer Stem Cell Research Institute (ECSCRI) |
| Publisher: | American Society for Microbiology |
| ISSN: | 0270-7306 |
| Last Modified: | 27 Oct 2022 08:46 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/63371 |
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