Chronic hypoxia remodels voltage-gated Ca2+ entry in a human airway chemoreceptor cell line

Colebrooke, R. L., Smith, I. F., Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X and Peers, C. 2002. Chronic hypoxia remodels voltage-gated Ca2+ entry in a human airway chemoreceptor cell line. Neuroscience Letters 318 (2) , pp. 69-72. 10.1016/S0304-3940(01)02479-X

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Abstract

Arterial and airway chemoreceptors respond to acute hypoxia by depolarizing, thereby activating voltage-gated Ca2+ channels and so permitting Ca2+entry to trigger transmitter release. Following periods of prolonged hypoxia, these cells undergo a form of remodelling which involves altered expression of ion channels. Here, we use microspectrofluorimetric recordings of voltage-gated Ca2+ entry (activated by exposure of cells to 50 mM K+) to show that chronic hypoxia suppresses such Ca2+ entry in model airway chemoreceptor (H146) cells. Furthermore, Ca2+ entry via L-type channels is suppressed, whilst entry via N-type channels is greatly enhanced. The suppressed response, together with dramatic remodelling of routes available for voltage-gated Ca2+ entry, is likely to alter significantly the acute O2 sensing properties of these cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0304-3940
Last Modified:	27 Oct 2022 08:48
URI:	https://orca.cardiff.ac.uk/id/eprint/63420

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