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Interferon-γ and atherosclerosis: pro- or anti-atherogenic?

Harvey, E. J. and Ramji, Dipak Purshottam ORCID: 2005. Interferon-γ and atherosclerosis: pro- or anti-atherogenic? Cardiovascular Research 67 (1) , pp. 11-20. 10.1016/j.cardiores.2005.04.019

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Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-γ (IFN-γ) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-γ regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-γ in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-γ signaling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Atherosclerosis; cytokines; foam cell; inflammation; interferon-γ.
Publisher: Oxford
ISSN: 0008-6363
Last Modified: 27 Oct 2022 08:48

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