Synthesis and antioxidant activities of novel chiral ebselen analogues

Elsherbini, Mohamed Sobh, Hamama, Wafaa S., Zoorob, Hanafi H., Bhowmick, Debasish, Mugesh, Govindasamy and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2014. Synthesis and antioxidant activities of novel chiral ebselen analogues. Heteroatom Chemistry 25 (5) , pp. 320-325. 10.1002/hc.21164

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Abstract

Novel chiral analogues of the antioxidant, anti-inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2-(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Additional Information:	Article first published online: 9 MAY 2014
Publisher:	Wiley-Blackwell
ISSN:	1042-7163
Date of Acceptance:	23 March 2014
Last Modified:	27 Oct 2022 08:52
URI:	https://orca.cardiff.ac.uk/id/eprint/63618

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