Determinant spreading and the dynamics of the autoimmune T-cell repertoire [review]

Lehmann, P. V., Sercarz, E. E., Forsthuber, T., Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462 and Gammon, G. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire [review]. Immunology Today 14 (5) , pp. 203-208. 10.1016/0167-5699(93)90163-f

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Abstract

In this article the authors propose a dynamic model of autoimmunity with T-cell recruitment and selection leading to changes in the specificity of the anti-self response during the course of disease. They argue that these changes are due to alterations in self-antigen presentation that lead to the display of previously cryptic self-determinants. Mechanisms that could underlie this differential self-presentation are proposed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0167-5699
Last Modified:	27 Oct 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/63681

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