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F-actin cytoskeletal organization in intervertebral disc health and disease

Blain, Emma Jane ORCID:, Li, S. and Duance, Victor Colin ORCID: 2007. F-actin cytoskeletal organization in intervertebral disc health and disease. Biochemical Society Transactions 35 (4) , pp. 683-685. 10.1042/BST0350683

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The cytoskeleton, which in most cell types, including the intervertebral disc described here, comprises microfilaments, microtubules and intermediate filaments, plays important functions in many fundamental cellular events, including cell division, motility, protein trafficking and secretion. The cytoskeleton is also critical for communication; for example, alterations to the architecture of the F-actin (filamentous actin) cytoskeletal networks can affect communication between the cells and the extracellular matrix, potentially compromising tissue homoeostasis. Although there are limited studies to date, this paper aims to review current knowledge on F-actin cytoskeletal element organization in intervertebral disc cells, how F-actin differs with pathology and its implications for mechanotransduction.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Uncontrolled Keywords: actin, aging, cytoskeleton, intervertebral disc, mechanotransduction.
Publisher: Portland Press
Last Modified: 27 Oct 2022 09:10

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