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Genetics of schizophrenia

Rees, Elliott ORCID:, O'Donovan, Michael Conlon ORCID: and Owen, Michael John ORCID: 2015. Genetics of schizophrenia. Current Opinion in Behavioral Sciences 2 , pp. 8-14. 10.1016/j.cobeha.2014.07.001

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Schizophrenia is a common psychiatric disorder with a strong genetic component. Recent studies applying new genomic technology to large samples have yielded substantial advances in identifying specific, associated DNA variants as well as clarifying the underlying genetic architecture of the disorder. The genetic liability of schizophrenia is now established as polygenic, with risk alleles in many genes existing across the full allelic frequency spectrum. It has also become apparent that schizophrenia shares risk alleles with other neuropsychiatric phenotypes, such as bipolar disorder, major depressive disorder, autism spectrum disorder, intellectual disability and attention-deficit hyperactivity disorder. These risk variants aggregate in several sets of functionally related genes, thereby providing novel insights into disease pathogenesis and opportunities for research into discovering new treatments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Publisher: Elsevier
ISSN: 2352-1546
Funders: MRC
Date of First Compliant Deposit: 30 March 2016
Last Modified: 03 May 2023 19:26

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