Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase

Blayney, Lynda Mary, Gapper, Peter William James and Newby, Andrew C. 1991. Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase. Biochemical Journal 273 (3) , pp. 803-806.

Full text not available from this repository.

Abstract

We have further characterized a putative receptor-operated Ca21 channel that is activated by histamine and guanosine 5'-[/ly-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMPdependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Portland Press
ISSN:	0264-6021
Related URLs:	hhttp://www.ncbi.nlm.nih.gov/pubmed/1705...
Last Modified:	31 Jan 2020 04:19
URI:	https://orca.cardiff.ac.uk/id/eprint/65161

Citation Data

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item