Phytoestrogen concentrations in serum from Japanese men and women over forty years of age

Morton, Michael S., Arisaka, Osamu, Miyake, Noriko, Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025 and Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008 2002. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. Journal of Nutrition 132 (10) , pp. 3168-3171.

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Abstract

Asian individuals have much lower incidences of prostate and breast cancer than populations from Western developed countries. They also consume a lower fat, higher fiber diet, with a large intake of phytoestrogens. These phytoestrogens may protect against hormone-dependent cancers and other diseases. Our study used established gas chromatography-mass spectrometry (GC-MS) methodologies to measure the concentrations of four phytoestrogens (daidzein, genistein, equol and enterolactone) in serum samples obtained from Japanese men (n = 102) and women (n = 125) > 40 y old. The results were compared with those obtained with samples from the UK. The Japanese men and women had higher (P < 0.001) concentrations of circulating daidzein, genistein and equol than individuals from the UK. The mean concentration of genistein in Japanese men, for example, was 492.7 nmol/L, compared with 33.2 nmol/L in men from the UK. The two populations, however, had similar serum concentrations of enterolactone. Furthermore, 58% of the Japanese men and 38% of the Japanese women had equol concentrations > 20 nmol/L, compared with none of the UK men and 2.2% of the UK women. These results support previously published GC-MS results from studies with low numbers of samples.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	phytoestrogens; soy; Japanese; serum
Publisher:	Rockville, MD : American Society for Nutrition
ISSN:	0022-3166
Last Modified:	27 Oct 2022 09:21
URI:	https://orca.cardiff.ac.uk/id/eprint/65334

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