Nitric oxide regulation of adult neurogenesis

Gray, William Peter and Cheung, Angela 2014. Nitric oxide regulation of adult neurogenesis. Litwack, Gerald, ed. Vitamins and Hormones, Vol. 96. Elsevier, pp. 59-77. (10.1016/B978-0-12-800254-4.00004-0)

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Abstract

The ubiquitous gaseous signaling molecule nitric oxide participates in the regulation of a variety of physiological and pathological processes, including adult neurogenesis. Adult neurogenesis, or the generation of new neurons in the adult brain, is a restricted event confined to areas with neurogenic capability. Although nitric oxide has been shown to mediate conflicting effects on adult neurogenesis, which may be partly explained by its unique characteristics, more studies are required in order to fully comprehend and appreciate the mechanisms involved. Neuropeptide Y, a neurotransmitter shown to be an important regulator of adult hippocampal neurogenesis, acts through intracellular nitric oxide to induce an increase in neural progenitor cell proliferation.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISBN:	9780128002544
ISSN:	0083-6729
Last Modified:	13 Sep 2024 01:10
URI:	https://orca.cardiff.ac.uk/id/eprint/65552

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