Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms

Galay-Burgos, Malyka, Gealy, Elizabeth Claire, Navarro-Martín, Laia, Piferrer, Francesc, Zanuy, Silvia and Sweeney, Glen E. 2006. Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology 145 (1) , pp. 47-53. 10.1016/j.cbpa.2006.04.028

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Abstract

Aromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass, Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1095-6433
Last Modified:	14 Jun 2022 07:39
URI:	https://orca.cardiff.ac.uk/id/eprint/65583

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