Aspects of steroid metabolism in the normal and neoplastic mammary gland of the bitch

d'Arville, C. N., Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Borthwick, G. and Pierrepoint, C. G. 1980. Aspects of steroid metabolism in the normal and neoplastic mammary gland of the bitch. Journal of Steroid Biochemistry 13 (12) , pp. 1407-1411. 10.1016/0022-4731(80)90051-5

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Abstract

Normal and neoplastic canine mammary tissues have been incubated with radio-labelled progesterone, testosterone and androstenedione and metabolites isolated. In both tissues the most active enzyme demonstrated was 5α-reductase. Testosterone was converted to the more active androgen 5α-dihydrotes-tosterone only in the tumours. A reversal of the 3β-hydroxysteroid Δ4−5 isomerase enzyme system was noted without the addition of cofactors. Epitestosterone was formed from both testosterone and andros-tenedione in the tumours only.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0022-4731
Last Modified:	27 Oct 2022 09:26
URI:	https://orca.cardiff.ac.uk/id/eprint/65801

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