Base-promoted new C--C bond formation: an expedient route for the preparation of thiazolo- and imidazolo-pyridinones via Michael addition

Yıldırım, Muhammet, Çelikel, Derya, Evis, Naciye, Knight, David William and Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897 2014. Base-promoted new C--C bond formation: an expedient route for the preparation of thiazolo- and imidazolo-pyridinones via Michael addition. Tetrahedron 70 (35) , pp. 5674-5681. 10.1016/j.tet.2014.06.070

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Abstract

Base-catalyzed one-pot cyclocondensation reactions of acryloyl and cinnamoyl chlorides with β-nitroenamine derivatives have been performed under mild conditions and target 7-substituted thiazolo-[3,2-a] or imidazolo-[1,2-a]pyridin-5-one derivatives were prepared successfully in moderate to good yields. The cyclization reactions may proceed via Michael addition followed by iminoketene-amide tautomerization in view of the products formed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Elsevier
ISSN:	0040-4020
Last Modified:	06 May 2023 01:31
URI:	https://orca.cardiff.ac.uk/id/eprint/66117

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