McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Quintiliani, Maurizio, Andrei, Graciela, Snoeck, Robert, Henson, Geoffrey and Balzarini, Jan 2009. 2 '-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743. Biorganic and Medicinal Chemistry Letters 19 (22) , pp. 6264-6267. 10.1016/j.bmcl.2009.09.116 |
Official URL: http://dx.doi.org/10.1016/j.bmcl.2009.09.116
Abstract
We report the preparation of 2′-α-F, 2′-β-F and 2′,2′-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the β-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the α-fluoro- and 2′,2′-difluoro BCNA derivatives were markedly less (∼100-fold) antivirally active.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Pharmacy Systems Immunity Research Institute (SIURI) |
Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
Uncontrolled Keywords: | VZV; BCNAs; Cf 1743; Thymidine kinase; Zoster; Shingles; Nucleosides; Herpes; Fluorosugars |
Publisher: | Elsevier |
ISSN: | 0960-894X |
Last Modified: | 17 Oct 2022 10:03 |
URI: | https://orca.cardiff.ac.uk/id/eprint/6641 |
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