Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids

Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Singhrao, Sim K., Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Bryce, Richard B., Horrobin, David F., Puntis, Malcolm C. A. and Mansel, Robert Edward ORCID: https://orcid.org/0000-0002-8051-0726 1997. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. Clinical and Experimental Metastasis 15 (6) , pp. 593-602. 10.1023/A:1018435229087

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Abstract

Desmosomes are key structures in cell-cell adhesion. In this study we examined the effect of n-6 essential fatty acids on the expression of desmoglein (Dsg), desmosomal cadherin and the formation of desmosomes in E-cadherin negative human breast, colon and lung cancer cells and melanoma cells. Electron microscopy revealed that cells cultured with gamma linolenic acid (GLA) showed increased cell-cell adhesion together with an increase in the formation of desmoglein-containing desmosomes. Western blotting studies of cellular proteins demonstrated that, following culture with fatty acids, Dsg expression was modified, with the greatest increase seen after GLA treatment. Other fatty acids increased Dsg expression, but to a lesser extent. It is concluded that GLA regulates desmosome-mediated cell-cell adhesion in human cancer cells, particularly in cells without E-cadherin.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Publisher:	Springer Verlag
ISSN:	0262-0898
Last Modified:	14 Nov 2022 07:46
URI:	https://orca.cardiff.ac.uk/id/eprint/66533

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