[Biochemical features and functional activities of hepatic endocytic compartment in the liver cell]

Enrich, C. and Evans, William Howard 1990. [Biochemical features and functional activities of hepatic endocytic compartment in the liver cell]. Revista española de fisiología 46 (1) , pp. 95-101.

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Abstract

When many ligands, polypeptidic hormones, growth factors, metabolic carriers, plasma glycoproteins, etc., bind to cell-surface receptors, ligand-receptor complexes are internalized by a process called receptor-mediated endocytosis towards the endocytic compartment. The endocytic compartment is an extensive network of anastomosing vesiculo-tubular membranes that differs biochemical and functionally from other intracellular organelles. Endosome fractions were prepared and antibodies raised against endosome membrane proteins. In addition to a detailed biochemical study of proteins and glycoproteins the antibodies were used to immunolocalize the endocytic structures in the hepatic cell. These studies aided to demonstrate the involvement of endocytic compartment not only in the sorting of proteins to specific domains of the plasma membrane but in the identification of "resident" endosome components.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Consejo Superior de Investigaciones Científicas
ISSN:	0034-9402
Last Modified:	17 Mar 2021 02:54
URI:	https://orca.cardiff.ac.uk/id/eprint/66639

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