CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro

Bermudez-Fajardo, A., Yliharsila, M., Evans, William Howard, Newby, A. C. and Oviedo-Orta, E. 2007. CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro. Journal of leukocyte biology 82 (3) , pp. 608-612. 10.1189/jlb.0307134

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Abstract

Gap junction channels constructed of connexins (Cxs) are expressed by peripheral and secondary lymphoid organ-derived lymphocytes. These channels in the plasma membrane play key roles in a range of lymphocyte functions exemplified by the synthesis and secretion of Igs and cytokines and during transmigration across the endothelium. Most recently, their involvement in antigen cross-presentation has also been established. We report here for the first time the expression of mRNA and protein encoding Cx43 in mouse-derived CD4+ Th0, Th1, and Th2 lymphocyte subpopulations and demonstrate the establishment gap junction channel formation with primary macrophages in vitro. We show that this mode of direct communication is particularly favored in Th1-macrophage interactions and that LPS inhibits lymphocyte-macrophage cross-talk independently of the subset of lymphocyte involved. Our work suggests that gap junction-mediated communication can be modulated in the absence of specific antigenic stimulation. Therefore, a further mechanism featuring gap junction-mediated communication may be implicated in immune regulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Society for Leukocyte Biology
ISSN:	0741-5400
Last Modified:	17 Mar 2021 02:55
URI:	https://orca.cardiff.ac.uk/id/eprint/66709

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