Behavioral recovery after transplantation into a rat model of Huntington's disease: Dependence on anatomical connectivity and extensive postoperative training

Brasted, Peter J., Watts, Colin, Torres, Eduardo Miguel, Robbins, Trevor W. and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2000. Behavioral recovery after transplantation into a rat model of Huntington's disease: Dependence on anatomical connectivity and extensive postoperative training. Behavioral Neuroscience 114 (2) , pp. 431-436. 10.1037//0735-7044.114.2.431

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Abstract

Rats were trained to perform a conditioned stimulus–response task known to be sensitive to striatal damage, after which they received unilateral excitotoxic striatal lesions. The subsequent implantation of graft tissue into the lesioned striatum was either immediate (9 days) or substantially delayed (70 days). When retested 14 weeks later, all graft and lesion rats were equally impaired initially and biased their responding toward the ipsilateral side. Graft-associated recovery was evident with repeated postoperative testing, but only in rats that had received transplants 9 days postlesion. It is suggested that this training-dependent, graft-associated recovery is mediated specifically by the restored host–graft connections.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	American Psychological Association
ISSN:	0735-7044
Last Modified:	27 Oct 2022 09:37
URI:	https://orca.cardiff.ac.uk/id/eprint/66792

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