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Binding cross-reactivity of Boc-phenylalanine enantiomers on molecularly imprinted polymers

Allender, Christopher John, Brain, Keith Roger and Heard, Charles Martin ORCID: 1997. Binding cross-reactivity of Boc-phenylalanine enantiomers on molecularly imprinted polymers. Chirality -New York- 9 (3) , pp. 233-237. 10.1002/(SICI)1520-636X(1997)9:3<233::AID-CHIR5>3.0.CO;2-G

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A potential problem associated with molecularly imprinted polymer (MIP) sorbents is that of cross-reactivity. In this study three MIPs (imprinted with Boc-L-phenylalanine, Boc-L-alanine, Boc-L-glutamic acid) plus a non-imprinted control were prepared and examined for their ability to bind differentially the enantiomers of boc-protected phenylalanine in an effort to quantify cross-reactivity and to develop a predictive model. Batch rebinding studies showed a degree of predictability for a number of MIP-ligand pairs, but other combinations showed unexpectedly high levels of cross-reactivity. Despite the general acceptance of heterogeneity of MIP binding sites, many previous studies report linear Scatchard plots, which is indicative of binding site homogeneity. The data from this study produced curves, clearly demonstrating heterogeneity. The theoretical and practical implications of this heterogeneity are discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Wiley-Blackwell
ISSN: 0899-0042
Last Modified: 13 Feb 2024 12:51

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