Metabotropic regulation of extrasynaptic GABAA receptors

Connelly, William M., Errington, Adam Clarke ORCID: https://orcid.org/0000-0002-2171-389X, Giovanni, Giuseppe Di and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2013. Metabotropic regulation of extrasynaptic GABAA receptors. Frontiers in Neural Circuits 7 , 171. 10.3389/fncir.2013.00171

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Abstract

A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under regulation. Here we review the mechanisms by which tonic inhibition is known to be modulated, and outline the potential behavioral consequences of this modulation. Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the tonic GABAA current, and how G-protein coupled receptors can regulate tonic inhibition through these effectors. We then speculate about the possible functional consequences of regulating the magnitude of the tonic GABAA current.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	Frontiers
ISSN:	1662-5110
Date of Acceptance:	3 October 2013
Last Modified:	27 Oct 2022 09:44
URI:	https://orca.cardiff.ac.uk/id/eprint/67580

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