Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent?

Davis, Brittany A. and Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712 2014. Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent? European Journal of Neuroscience 39 (11) , pp. 1933-1942. 10.1111/ejn.12607

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Abstract

Rodent models are a key factor in the process of translating psychiatric genetics and genomics findings, allowing us to shed light on how risk-genes confer changes in neurobiology by merging different types of data across fields, from behavioural neuroscience to the burgeoning omics (e.g. genomics, epigenomics, proteomics, etc.). Moreover, they also provide an indispensable first step for drug discovery. However, recent evidence from both clinical and genetic studies highlights possible limitations in the current methods for classifying psychiatric illness, as both symptomology and underlying genetic risk are found to increasingly overlap across disorder diagnoses. Meanwhile, integration of data from animal models across disorders is currently limited. Here, we argue that behavioural neuroscience is in danger of missing informative data because of the practice of trying to ‘diagnose’ an animal model with a psychiatric illness. What is needed is a shift in emphasis, from seeking to ally an animal model to a specific disorder, to one focused on a more systematic assessment of the neurobiological and behavioural outcomes of any given genetic or environmental manipulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	0953-816X
Last Modified:	27 Oct 2022 09:44
URI:	https://orca.cardiff.ac.uk/id/eprint/67581

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