Immunocompetent for immunotherapy? A study of the immunocompetence of cervical cancer patients

Fiander, Alison Nina, Adams, M., Evans, A. S., Bennett, A. J. and Borysiewicz, L. K. 1995. Immunocompetent for immunotherapy? A study of the immunocompetence of cervical cancer patients. International Journal of Gynecological Cancer 5 (6) , pp. 438-442. 10.1046/j.1525-1438.1995.05060438.x

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Abstract

Sixty-five patients with cervical carcinoma and 17 control subjects were studied to determine immunocompetence as a prerequisite for immunotherapy using live virus vectors. T-cell immunity, measured by surface phenotype and proliferative assays, was reduced with increasing volume of invasive disease, and independent of treatment effects. Both the CD4+ and CD8+ subsets were affected so that the CD4:8 ratio remained within normal limits. In contrast B-cell number, immunoglobulins and complement were normal as were in vivo responses to a polysaccharide vaccine. Thus, determination of immunocompetence prior to use of live vector immunotherapy requires assessment of each individual subject, especially in those with advanced disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Lippincott, Williams & Wilkins
ISSN:	1048-891X
Last Modified:	16 Apr 2020 01:23
URI:	https://orca.cardiff.ac.uk/id/eprint/67703

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