Sensing change: The emerging role of calcium sensors in neuronal disease

Seaton, Gillian, Hogg, Ellen L., Jo, Jihoon, Whitcomb, Daniel J. and Cho, Kwangwook 2011. Sensing change: The emerging role of calcium sensors in neuronal disease. Seminars in Cell and Developmental Biology 22 (5) , pp. 530-535. 10.1016/j.semcdb.2011.07.014

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Abstract

Calcium (Ca2+) is a fundamental intracellular signalling molecule in neurons. Therefore, significant interest has been expressed in understanding how the dysregulation of Ca2+ signals might impact on neuronal function and the progression of different disease states. Many previous studies have examined the role of Ca2+ in neuronal excitotoxicity and some have started to understand how Ca2+ dysregulation might be a cause or consequence of neurodegeneration. This review will therefore focus on the significance of Ca2+ sensors, proteins that transduce Ca2+ signals, in neuronal function and dysfunction. Finally, we will assess their potential role in neurodegenerative processes, such as Alzheimer's disease (AD), arguing that they could serve as potential therapeutic targets.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1084-9521
Last Modified:	04 Jun 2017 07:46
URI:	https://orca.cardiff.ac.uk/id/eprint/67832

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