Shires, Katherine L., Da Silva, B. M., Hawthorne, J. P., Morris, R. G. M. and Martin, S. J. 2012. Synaptic tagging and capture in the living rat. Nature Communications 3 , 1246. 10.1038/ncomms2250 |
Abstract
In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons—a phenomenon known as ‘synaptic tagging and capture’. Here we show that the same phenomenon occurs in the intact rat. Late long-term potentiation can be induced in CA1 during the inhibition of protein synthesis if an independent input is strongly tetanized beforehand. Conversely, declining early long-term potentiation induced by weak tetanization can be converted into lasting late long-term potentiation by subsequent strong tetanization of a separate input. These findings indicate that synaptic tagging and capture is not limited to in vitro preparations; the past and future activity of neurons has a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory persistence.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Publisher: | Nature Publishing Group |
ISSN: | 2041-1723 |
Date of Acceptance: | 1 November 2012 |
Last Modified: | 05 Sep 2020 01:33 |
URI: | https://orca.cardiff.ac.uk/id/eprint/67840 |
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