Exploration of new methods involved for the synthesis of PET tracers

Marie, Guillaume 2014. Exploration of new methods involved for the synthesis of PET tracers. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

This work describes the development and the optimisation of microfluidic radiolabelling by using an Eckert & Ziegler device remotely controlled by a computer to perform the multistep synthesis of [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG). This device was then modified to control the fluidic transfers via flow of nitrogen and vacuum with the aid of a new one-way cassette system by using different concentrations of water for the Kryptofix solution. A new route was also explored to perform florbetaben ([18F]-BAY94- 9172), a potent Alzheimer’s disease PET tracer. Chapter 1 is an overview of positron emission tomography techniques to synthesise tracers. Chapter 2 is a brief introduction of the PETIC centre (Wales), where the fluoride-18 was delivered to produce [18F]-FDG. Chapter 3 describes the reaction of the [K+⊂2.2.2]18F− complex on mannose triflate and the variety of products formed. The Eckert & Ziegler platform was furnished with a cassette module and a microfluidic tubing to perform the radiolabelling fluorination of mannose triflate to the tetraacetate [18F]-deoxy-D-glucose and [18F]-FDG. Chapter 4 is focused on the modifications on the Eckert & Ziegler modules by using 1-way cassettes to limit the use of mechanical valves. [18F]-FDG was synthesised via a semiautomated procedure by limiting the number of modules present in the hot cell. Chapter 5 is an investigation for the preparation of several triethylene glycol derivatives following the syntheses of Kryptofix [2.2.2]. The use of triethylene glycol chain will be essential for the synthesis of the Florbetaben precursor. The Chapter 6 is the exploration of a new synthetic route leading to the precursor of florbetaben.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Oct 2023 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/67939

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