CACNA1C risk variant affects reward responsiveness in healthy individuals

Lancaster, Thomas ORCID: https://orcid.org/0000-0003-1322-2449, Heerey, E. A., Mantripragada, Kiran Kumar ORCID: https://orcid.org/0000-0003-2070-8105 and Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 2014. CACNA1C risk variant affects reward responsiveness in healthy individuals. Translational Psychiatry 4 (10) , e461. 10.1038/tp.2014.100

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Abstract

The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. We investigated whether this risk variant affects reward responsiveness because reward processing is one of the central cognitive-motivational domains implicated in both disorders. In a sample of 164 young, healthy individuals, we show a dose-dependent response, where the rs1006737 risk genotype was associated with blunted reward responsiveness, whereas discriminability did not significantly differ between genotype groups. This finding suggests that the CACNA1C risk locus may have a role in neural pathways that facilitate value representation for rewarding stimuli. Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nature Publishing Group
ISSN:	2158-3188
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Last Modified:	11 May 2023 05:47
URI:	https://orca.cardiff.ac.uk/id/eprint/68080

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