White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158, Curtin, Nicola J., Eastman, Brian W., Golding, Bernard T., Hostomsky, Zdenek, Kyle, Suzanne, Li, Jianke, Maegley, Karen A., Skalitzky, Donald J., Webber, Stephen E., Yu, Xiao-Hong and Griffin, Roger J. 2004. Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. Biorganic and Medicinal Chemistry Letters 14 (10) , pp. 2433-2437. 10.1016/j.bmcl.2004.03.017 |
Official URL: http://dx.doi.org/10.1016/j.bmcl.2004.03.017
Abstract
The synthesis and biological evaluation of a new series of amine-substituted 2-arylbenzimidazole-4-carboxamide inhibitors of the DNA-repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is reported. The introduction of an amine substituent at the 2-aryl position is not detrimental to activity, with most inhibitors exhibiting Ki values for PARP-1 inhibition in the low nanomolar range. Two compounds in this series were found to potentiate the cytotoxicity of the DNA-methylating agent temozolomide by 4–5-fold in a human colorectal cancer cell line.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Pharmacy |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Publisher: | Elsevier |
ISSN: | 0960-894X |
Last Modified: | 27 Oct 2022 09:55 |
URI: | https://orca.cardiff.ac.uk/id/eprint/68212 |
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