Goyal, R., Shankar, Jai, Fone, David Lawrence  ORCID: https://orcid.org/0000-0002-6476-4881 and Hughes, D.
2001.
Randomised controlled trial of ketorolac in the management of korneal abrasions.
Acta Ophthalmologica Scandinavica
79
(2)
, pp. 177-179.
10.1034/j.1600-0420.2001.079002177.x
|
Abstract
Purpose: To evaluate the role of topical non-steroidal anti-inflammatory agents (NSAIDs) in the management of corneal abrasions with respect to symptoms and healing. Methods: The study was designed as a prospective, single center, randomised, placebo controlled, double-blinded trial. Eighty-eight consecutive patients with non-infective, non-contact lens related traumatic or foreign body removal related corneal abrasions were recruited to this study. They were randomised into two groups. Both groups were given a single instillation of Gutt. cyclopentolate 0.5% followed by chloramphenicol eye ointment four times a day until the following day. In addition, the treatment group received topical Ketorolac trometamol 0.5% ophthalmic solution while the control group received placebo Liquifilm tears. Patients were assessed at presentation and about twenty-four hours later for subjective symptoms, abrasion size and any associated complications. Results: There was no statistical difference in the two groups at base line and twenty-four hour follow-up when assessed for five subjective symptoms of pain, photophobia, grittiness, watering and blurring of vision. However, those receiving topical ketorolac required significantly less additional oral analgesics (p=0.001). There was no difference in the rate of healing. Conclusion: Use of topical ketorolac may be a useful adjunct in the management of corneal abrasions.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine |
| Publisher: | Wiley-Blackwell |
| ISSN: | 1395-3907 |
| Last Modified: | 27 Oct 2022 09:56 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/68272 |
Citation Data
Cited 24 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Dimensions
Dimensions